Research Scientist- Single cell biotechnology
Job description and selection criteria
Research Scientist in Single cell biotechnology
Synthetic biology and single cell biology
Environment and Biotechnology
Professor Wei Huang
A competitive remuneration package will apply
Fixed-term (3 years), with the possibility of extension.
1st July 2021
Application closing date
15 June, 2021
The group is focused on single cell biotechnology and synthetic biology. In OSCAR, single cell biotechnology will be applied to discovery of novel genes from natural environment and to personalised medicine. Please see above published papers for the background technology.
The vision of single cell Raman biotechnology is that single cell Raman spectra can be regarded as phenotypic profiles of individual cells, which reflect the physiological state and function of cells.
The main job duties of this post-holder will include: 1) application of Raman technology to single cell biology and medical diagnosis; 2) data analysis using advanced mathematical methods such as machine learning and artificial intelligence, 3) application of Raman technology to environmental microbiology and material science.
The research will include two topics: 1) exploiting single cell Raman technology to medical application. This will include working closely with Prof Zhanfeng Cui and Prof Hua Ye (Biomedical engineering in OSCAR) employing single cell Raman biotechnology to characterise stem cells, cancer cells and pathogens. 2) application of Raman technology to environmental microbiology and material science. This will jointly work with Prof Ian Thompson, Prof Ron Roy and Prof Jamie Warner in OSCAR and Chinese partners.
- Carry out research of single cell biotechnology, including Raman analysis and Raman activated cell sorting.
- Perform microbiology or molecular biology experiments, including molecular cloning.
- Carry out advanced data analysis including machine learning and artificial intelligence.
- Apply Raman single cell biotechnology to medical diagnosis and environmental research.
- Support the project team in integrating activities across the partner organisations, including liaison between research teams and carry out administrative roles as required.
- Prepare summary technical and progress review reports for project steering meetings, including preparation and delivery of oral presentations at such meetings.
- Prepare papers for journals, presentations and other research outputs either in-house or at national/international conferences or seminars, to disseminate research findings.
- Contribute to the maintenance of the project web pages for the consortium.
- Provide help to other researchers in the same or related field of research, as requested by the project PI.
- Read academic papers, journals and textbooks and attend conferences to keep up-to-date with new developments in the field
- Undertake other duties to be assigned by the project team, as required.
- Adapt existing and develop new scientific techniques and experimental protocols
- Test hypotheses and analyse scientific data from a variety of sources, reviewing and refining working hypotheses as appropriate
- Use specialist scientific equipment in a laboratory environment
- Coordinate OSCAR activity with PIs and Oxford research team, in particular the teams lead by Professors Zhanfeng Cui, Hua Ye, Ian Thompson, Ron Roy and Jamie Warner.
- Manage own academic research. This involves small scale project management, to co-ordinate multiple aspects of work to meet deadlines
- Contribute ideas for new research projects
- Develop ideas for generating research income, and present detailed research proposals to senior researchers
- Collaborate in the preparation of scientific reports and journal articles and occasionally present papers and posters
- Act as a source of information and advice to other members of the group on scientific protocols and experimental techniques
- Represent the research group at external meetings/seminars, either with other members of the group and collaborative industrial partners.
- Carry out collaborative projects with colleagues in partner institutions, and research groups and in particular with industry.
- The post may have the opportunity to teach or undertake ad-hoc paid teaching (this includes lecturing, demonstrating, small-group teaching, tutoring of undergraduates and graduate students and supervision of Masters projects in collaboration with principal investigators). Permission must be sought in advance for each opportunity and the total must not exceed 4 hours a week.
- Strong background in Raman spectroscopy.
- Strong background on microbiology or cell biology.
- Good background related to stem cell, cancer and medical microbiology.
- Hold a relevant PhD/DPhil (or be near completion), together with relevant experience
- Possess sufficient specialist knowledge in the discipline to work within established research programmes and help train/supervise junior members of the lab.
- Ability to manage own academic research and associated activities
- Previous experience of contributing to publications/presentations
- Ability to contribute ideas for new research projects and research income generation
- Excellent communication skills, including the ability to write for publication, present research proposals and results, and represent the research group at meetings
- Experience on medical microbiology or cancer or stem cells.
- Ideally familiar with data analysis and machine learning.
- Experience of independently managing a discrete area of a research project
- Experience of actively collaborating in the development of research articles for publication
- Xu, J., Zhu, D., Ibrahim, A.D., Allen, C.R., Gibson, C.M. Fowler, P.W., Song, Y. Huang, W.E. (2017) Raman-DIP (Deuterium Isotope Probing) reveals microbial metabolism at the single-cell level. Analytical Chemistry 89:13305-13312.
- Rampley, C.P.N., Davison, P.A., Qian, P., Preston, G.M., Hunter, C.N., Thompson, P.I., Wu, L.J., Huang, W.E. (2017) Development of SimCells as a novel chassis for functional biosensors. Scientific Reports 7: 7261.
- Song, Y., Kaster, A., Vollmers, J., Song, Y., Davison, P.A., Frentrup, M., Preston, G.M., Thompson, I.P., Murrell, J.C., Yin, H., Hunter, C.N., Huang, W.E. (2017) Single cell genomics based on Raman sorting reveals novel carotenoid-containing bacteria in the Red Sea. Microbial Biotechnology. 10:125-137. (Top 1% paper in Web Science)
- Berry, D., Mader, E., Woebken, D., Wang, Y., Zhu, D., Lee, T.K. Palatinszky, M., Schintlmeister, A., Schmid, M., Shterzer, N., Mizrahi, I., Rauch, I., Decker, T., Bocklitzg, T., Popp, J., Gibson, C.M., Fowler, P.W., Huang, W.E., Wagner, M. (2015) Tracking heavy water (D2O) incorporation for identifying and sorting active microbial cells. Proceedings of the National Academy of Sciences of the United States of America 112:E194-203. (Top 1% paper in Web Science)
- Li et al., (2012) Rapid resonance Raman microspectroscopy to probe carbon dioxide fixation by single cells in microbial communities. ISME Journal 6:875-885.
- Song, Y.Z., Hahn, T., Thompson, I.P., Mason, T.J., Preston, G.M., Li, G.H. Paniwnyk, L. and Huang, W.E.*. (2007) Ultrasound-mediated DNA transfer for bacteria. Nucleic Acids Research 35: e129.
- Yizhi Song, Guanghe Li, Steven F. Thornton, Ian P. Thompson, Steven A. Banwart, David N. Lerner and Huang, W.E.* (2009) Optimization of Bacterial Whole Cell Bioreporters for Toxicity Assay of Environmental Samples. Environmental Science & Technology 43: 7931-7938.
- Huang, W.E., Wang, H., Zheng, H.J., Huang, L.F., Singer, A.C., Thompson, I., and Whiteley, A.S. (2005) Chromosomally located gene fusions constructed in Acinetobacter sp. ADP1 for the detection of salicylate. Environmental Microbiology 7: 1339-1348.
- Huang, W.E.*, Griffiths, R.I., Thompson, I.P., Bailey, M.J., and Whiteley, A.S. (2004) Raman microscopic analysis of single microbial cells. Analytical Chemistry 76: 4452-4458.
- Alkane production - Biodiesel Synthesis by Bacteria, WO2013/128184.
About OSCAR (Oxford Suzhou Centre for Advanced Research)
OSCAR, the first overseas research centre of the University of Oxford, is working closely with the Suzhou Industrial Park and both academic and industrial collaborators in China to progress a range of exciting societal and economic development opportunities.
As a multidisciplinary research, innovation and technology centre, OSCAR focuses on research challenges and technologies that both complement the Centre’s location in Suzhou Industrial Park and capitalise on current Oxford research strengths. Research will initially be focused around the areas of biomedical engineering, biomedicine, advanced functional materials, electronic / optoelectronic / photonic devices, environmental technology, energy, mathematical and computational applications in finance and in health, and other related science and engineering disciplines.
The Centre is positioned in Suzhou Dushu Lake Science and Education Innovation District (SEID), a district in southern SIP with a high concentration of science, education and innovation activity. SEID is the prototype of higher education internationalization in China which hosts 32 local and foreign universities and institutions. The Centre, housed in a nine-storey building with a gross space of 20,000m2, offers flexible access to facilities for multi-functional activities such as labs, seminars, workshops, training, public events, and administration, etc.
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Thank you for your interest in applying for posts at the Oxford-Suzhou Centre for Advanced Research (OSCAR). Please read the following tips to help you proceed with the application process.
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Oxford Suzhou Centre for Advanced Research